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Delta-8 动物胃肠道体内中药物的溶解度的测定——结论、工具书类！
来源：上海谓载 浏览 976 次 发布时间:2021-11-26
结论
胃肠道pH值和缓冲容量的种间差异是重要的考虑因素，尤其是对胃肠道给药的pHresponsive配方和可电离药物。 因此，兔子和猪的空肠、回肠和近端结肠具有相对较高的缓冲容量，而猪远端结肠具有较低的缓冲容量是非常重要的考虑因素。 与人相比，大鼠、兔和猪的近端小肠和升结肠的液体的渗透压和表面张力也较高。 胃肠道特征的这些差异导致泼尼松龙在大鼠体内的溶解度较高（近端结肠除外），而泼尼松龙在猪和兔体内的溶解度与人类相当。 因此，如果在大鼠的体液中测量，中性化合物泼尼松龙的溶解度可能被高估。 另一方面，可电离药物美沙拉秦在兔和猪体内的溶解度在小肠中部高于人，在结肠中低于人，仅在小肠远端与人相当。 胃肠道环境的差异，如pH值、缓冲容量、渗透压和表面张力，导致药物溶解度的差异。 在兔子和猪中，美沙拉秦的溶解度在沿胃肠道向下移动时发生显著变化，这在很大程度上受管腔液的pH值和渗透压的影响。
工具书类
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Delta-8 动物胃肠道体内中药物的溶解度的测定——摘要、介绍
Delta-8 动物胃肠道体内中药物的溶解度的测定——材料和方法